Influenza and Antibody-Dependent Cellular Cytotoxicity

Influenza-specific antibody-dependent cellular cytotoxicity: toward a universal influenza vaccine.

There is an urgent need for universal influenza vaccines that can control emerging pandemic influenza virus threats without the need to generate new vaccines for each strain. Neutralizing Abs to the influenza virus hemagglutinin glycoprotein are effective at controlling influenza infection but generally target highly variable regions. Abs that can mediate other functions, such as killing influe...

Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1.

BACKGROUND During the 2009 pandemic of influenza A virus subtype H1N1 (A[H1N1]pdm09) infection, older individuals were partially protected from severe disease. It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed. METHODS We tested serum specimens obtained from 182 individuals aged 1...

Standard trivalent influenza virus protein vaccination does not prime antibody-dependent cellular cytotoxicity in macaques.

Yearly vaccination with the trivalent inactivated influenza vaccine (TIV) is recommended, since current vaccines induce little cross neutralization to divergent influenza strains. Whether the TIV can induce antibody-dependent cellular cytotoxicity (ADCC) responses that can cross-recognize divergent influenza virus strains is unknown. We immunized 6 influenza-naive pigtail macaques twice with th...

Antibodies Antibodies in the Absence of Neutralizing Antibody-Dependent Cellular Cytotoxicity Cross-Reactive Influenza-Specific

Natural and Cytotoxicity Antibody-Dependent Cellular of Polymorphonuclear Leukocytes

OHARA, M., SHIRADO, M., MIYATA, M., SAKUMA, H., NANAMIYA, M., YOSHIDA, N., YOSHIDA, H. and KASUKAWA, R. Natural and Antibody-Dependent Cellular Cytotoxicity o f Polymorphonuclear Luekocytes. Tohoku J. exp. Med., 1983, 140 (1), 59-66 Cytotoxic activity of polymorphonuclear leukocytes (PMN) in the peripheral blood of patients with various diseases was demonstrated to K562 cells (natural cytotoxic...